PF-6274484 |
| رقم الكتالوجGC44613 |
PF-6274484 هو مثبط قوي لـ EGFR مع Kis من 0.14 نانومتر و 0.18 نانومتر لـ EGFR-L858R / T790M و WT EGFR ، على التوالييثبط PF-6274484 EGFR-L858R / T790M الفسفرة الذاتية في الخلايا السرطانية H1975 و EGFR WT في الخلايا السرطانية A549 مع IC50s من 6.6 و 5.8 نانومتر ، على التوالي
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Cas No.: 1035638-91-5
Sample solution is provided at 25 µL, 10mM.
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PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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