PF-6274484 |
| カタログ番号GC44613 |
PF-6274484 は、EGFR-L858R/T790M および WT EGFR の Kis がそれぞれ 0.14 nM および 0.18 nM の強力な EGFR 阻害剤です。 PF-6274484 は、H1975 腫瘍細胞で EGFR-L858R/T790M 自己リン酸化を阻害し、A549 腫瘍細胞で EGFR WT をそれぞれ 6.6 および 5.8 nM の IC50 で阻害します。
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Cas No.: 1035638-91-5
Sample solution is provided at 25 µL, 10mM.
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PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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