PF-6274484 |
| Catalog No.GC44613 |
Le PF-6274484 est un puissant inhibiteur de l'EGFR avec un Kis de 0,14 nM et 0,18 nM pour EGFR-L858R/T790M et WT EGFR, respectivement. Le PF-6274484 inhibe l'autophosphorylation de l'EGFR-L858R/T790M dans les cellules tumorales H1975 et de l'EGFR WT dans les cellules tumorales A549 avec des CI50 de 6,6 et 5,8 nM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1035638-91-5
Sample solution is provided at 25 µL, 10mM.
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PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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