PF-6274484 |
| Catalog No.GC44613 |
PF-6274484 es un potente inhibidor de EGFR con Kis de 0,14 nM y 0,18 nM para EGFR-L858R/T790M y WT EGFR, respectivamente. PF-6274484 inhibe la autofosforilaciÓn de EGFR-L858R/T790M en células tumorales H1975 y EGFR WT en células tumorales A549 con IC50 de 6,6 y 5,8 nM, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1035638-91-5
Sample solution is provided at 25 µL, 10mM.
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PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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