GPR84
GPR84 is a G protein-coupled receptor for medium-chain fatty acids. GPR84 is a receptor for free fatty acids and can be potently activated by saturated medium-chain free fatty acids (MCFAs) like decanoic acid, undecanoic acid and lauric acid. GPR84, a receptor for medium-length free fatty acids is upregulated on protein level in LPS activated tolerant CD14+ monocytes and THP-1 cells.
GPR84 is activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. GPR84 is now considered to be a member of FFA-sensing GPCRs. MCFAs with carbon chain lengths of 9–14 activate GPR84, coupling primarily to a pertussis toxin (PTX)-sensitive Gi/o pathway. GPR84 should be a proinflammatory receptor and may be a novel, attractive target for treating chronic low grade inflammation associated-diseases.
منتجات لـ نبسب؛ GPR84
- القط. رقم اسم المنتج بيانات
- GC11350 6-OAU 6-OAU (GTPL5846) (6-n-octylaminouracil) هو ناهض GPR84 (مستقبلات مقترنة بالبروتين 84) ، بقيمة EC50 تبلغ 105 نانومتر
- GC64229 GPR84 antagonist 1 مضاد GPR84 1 هو خصم تنافسي عالي الانتقاء وخصم GPR84 البشري
- GC31712 GPR84 antagonist 8 مضاد GPR84 8 هو مضاد انتقائي لـ GPR84
- GC31698 PBI-4050 sodium salt (Setogepram (sodium salt)) يعمل الصوديوم Fezagepras (Setogepram) بمثابة ناهض نشط عن طريق الفم لـ GPR40 وكمضاد أو ناهض عكسي لـ GPR84.