RU-302 |
| رقم الكتالوجGC64385 |
RU-302 هو مثبط عموم TAM الذي يحجب الواجهة بين المجال الخارجي TAM Ig1 ومجال Gas6 Lgيمنع RU-302 بشكل فعال تنشيط مستقبلات Axl المستحثة بالغاز 6 مع فحوصات خلية IC50in منخفضة الميكرومولار ، ويثبط نمو ورم سرطان الرئة
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Cas No.: 1182129-77-6
Sample solution is provided at 25 µL, 10mM.
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RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.
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