RU-302 |
| Catalog No.GC64385 |
RU-302 est un inhibiteur pan TAM qui bloque l'interface entre l'ectodomaine TAM Ig1 et le domaine Gas6 Lg. Le RU-302 bloque efficacement l'activation du récepteur Axl inductible par Gas6 avec une faible IC50 micromolaire dans les tests cellulaires et supprime la croissance tumorale du cancer du poumon.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1182129-77-6
Sample solution is provided at 25 µL, 10mM.
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RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.
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