RU-302 |
| Katalog-Nr.GC64385 |
RU-302 ist ein Pan-TAM-Inhibitor, der die Schnittstelle zwischen der TAM-Ig1-EktodomÄne und der Gas6-Lg-DomÄne blockiert. RU-302 blockiert effektiv die Gas6-induzierbare Aktivierung des Axl-Rezeptors mit einem niedrigen mikromolaren IC50 in Zellassays und unterdrÜckt das Wachstum von Lungenkrebstumoren.
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Cas No.: 1182129-77-6
Sample solution is provided at 25 µL, 10mM.
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RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.
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