RU-302 |
| Catalog No.GC64385 |
RU-302는 TAM Ig1 엑토도메인과 Gas6 Lg 도메인 사이의 인터페이스를 차단하는 범 TAM 억제제입니다. RU-302는 낮은 마이크로몰 IC50in 세포 분석으로 Gas6 유도성 Axl 수용체 활성화를 효과적으로 차단하고 폐암 종양 성장을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1182129-77-6
Sample solution is provided at 25 µL, 10mM.
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RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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