RU-302 |
| カタログ番号GC64385 |
RU-302 は、TAM Ig1 外部ドメインと Gas6 Lg ドメインの間の界面をブロックする汎 TAM 阻害剤です。 RU-302 は、細胞アッセイにおいて低マイクロモルの IC50 で Gas6 誘導性 Axl 受容体の活性化を効果的にブロックし、肺がんの腫瘍増殖を抑制します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1182129-77-6
Sample solution is provided at 25 µL, 10mM.
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RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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