TFC 007 |
| رقم الكتالوجGC50101 |
يُظهر TFC-007 ، وهو مثبط انتقائي للبروستاغلاندين D سينثيز (H-PGDS) ، نشاطًا مثبطًا عاليًا ضد إنزيم H-PGDS (قيمة IC 50 تبلغ 83 نانومتر)يمكن استخدام TFC-007 لتكوين محفز تدهور H-PGDS PROTAC (H-PGDS) -1 (يرتبط TFC-007 بـ H-PGDS ، ويرتبط بوماليدوميد بـ cereblon)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 927878-49-7
Sample solution is provided at 25 µL, 10mM.
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Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
Nabe et al (2011) Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95 27 PMID:21601002
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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