TFC 007 |
| Catalog No.GC50101 |
선택적 조혈 프로스타글란딘 D 합성 효소(H-PGDS) 억제제인 TFC-007은 H-PGDS 효소에 대한 높은 억제 활성을 나타냅니다(IC50 값 83nM). TFC-007은 H-PGDS 분해 유도제 PROTAC(H-PGDS)-1(TFC-007은 H-PGDS에 결합하고 Pomalidomide는 세레블론에 결합)을 구성하는 데 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 927878-49-7
Sample solution is provided at 25 µL, 10mM.
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Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
Nabe et al (2011) Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95 27 PMID:21601002
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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