GLPBio

Chromatin/Epigenetics

Read More about this category
Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1791)

  • GC91565 structure
    GC91565GSK199 analog (hydrochloride)
    CAS: 2048226-46-4
    Purity: >95.00%

    GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199.

  • GC91602 structure
    GC91602PFI-6
    CAS: 2675452-91-0
    Purity: >95.00%

    PFI-6 is a chemical probe for the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 140 and 160 nM, respectively).

  • GC91622 structure
    GC91622KAT8 Inhibitor 19
    CAS: 28532-21-0
    Purity: >98.00%

    KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM).

  • GC91689 structure
    GC91689TG46
    CAS: 936091-15-5
    Purity: >98.00%

    TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM).

  • GN10030 structure
    GN10030Fisetin
    CAS: 528-48-3
    Purity: >98.00%

    Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities.

  • GN10040 structure
    GN10040Dehydrocorydaline
    CAS: 30045-16-0
    Purity: >98.00%

    Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma.

  • GN10114 structure
    GN10114Oroxin A
    CAS: 57396-78-8
    Purity: >98.00%
  • GN10308 structure
    GN10308Chlorogenic acid
    CAS: 327-97-9
    Purity: >98.00%

    Chlorogensäure ist eine wichtige phenolische Verbindung in Kaffee und Tee.

  • GN10347 structure
    GN10347Nicotinamide (Vitamin B3)
    CAS: 98-92-0
    Purity: >99.50%

    Nicotinamide (Vitamin B3) ist ein Amid-Derivat von Vitamin B3. Nicotinamide (Vitamin B3) hemmt die Aktivität von SIRT1 (IC 50 : 50-180 μM) und SIRT2 (IC 50 : 2 μM). Zudem steigert Nicotinamide den Gehalt an NAD + , ATP und ROS in Zellen.

  • GN10357 structure
    GN10357Parthenolide
    CAS: 20554-84-1
    Purity: >98.00%

    Parthenolide ist ein NF-κB-Inhibitor mit IC 50 -Werten für Eca109-, KYSE-510-, SiHa- und MCF-7-Zellen von ungefähr 10.3, 13.3, 8.42 und 9.54μM nach 48 Stunden.

  • GN10413 structure
    GN10413Agrimol B
    CAS: 55576-66-4
    Purity: >99.50%
  • GN10442 structure
    GN10442Curculigoside
    CAS: 85643-19-2
    Purity: >99.50%
  • GN10452 structure
    GN10452Paeoniflorin
    CAS: 23180-57-6
    Purity: >98.00%

    Paeoniflorin is a pinane monoterpene glycoside extracted from the roots of Paeonia plants of the Ranunculaceae family, possessing multiple biological activities.

  • GN10473 structure
    GN10473Ginkgolide C
    CAS: 15291-76-6
    Purity: >98.00%
  • GN10518 structure
    GN10518Chitosamine hydrochloride
    CAS: 66-84-2
    Purity: >98.00%
  • GN10584 structure
    GN10584Ginsenoside Rk1
    CAS: 494753-69-4
    Purity: >98.00%
  • GN10627 structure
    GN10627Atractylenolide I
    CAS: 73069-13-3
    Purity: >98.00%
  • GN10629 structure
    GN106295,7-dihydroxychromone
    CAS: 31721-94-5
    Purity: >99.00%

    5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.

  • GN10669 structure
    GN10669Glucosamine sulfate
    CAS: 29031-19-4
    Purity: >98.00%
  • GP10020 structure
    GP10020Histone-H2A-(107-122)-Ac-OH
    Purity: >98%

    Histone-H2A peptide

  • GC11537 structure
    GC11537MK-4827 tosylate
    CAS: 1038915-73-9
    Purity: >99.50%

    MK-4827-Tosylat (MK-4827-Tosylat) ist ein hochwirksamer und oral bioverfÜgbarer PARP1- und PARP2-Inhibitor mit einem IC50 von 3,8 bzw. 2,1 nM. MK-4827-Tosylat fÜhrt zur Hemmung der Reparatur von DNA-SchÄden, aktiviert die Apoptose und zeigt AntitumoraktivitÄt.

  • GC12756 structure
    GC12756MK-4827 hydrochloride
    CAS: 1038915-64-8
    Purity: >99.50%

    MK-4827-Hydrochlorid (MK-4827-Hydrochlorid) ist ein hochwirksamer und oral bioverfÜgbarer PARP1- und PARP2-Inhibitor mit IC50-Werten von 3,8 bzw. 2,1 nM. MK-4827-Hydrochlorid fÜhrt zur Hemmung der Reparatur von DNA-SchÄden, aktiviert die Apoptose und zeigt AntitumoraktivitÄt.

  • GC17052 structure
    GC17052MK-4827 Racemate
    CAS: 1038915-75-1
    Purity: >98%

    selective inhibitor of PARP1/PARP2

  • GC11576 structure
    GC11576Tranylcypromine (2-PCPA) HCl
    CAS: 4548-34-9
    Purity: >98%

    (1S,2R)-Tranylcypromin ((1S,2R)-SKF 385) Hydrochlorid ist ein starkes Antidepressivum.