7-Ketolithocholic acid (Synonyms: 7-KLCA, 7-keto LCA, 7-oxo LCA, 7-keto Lithocholate, 7-oxo Lithocholate, 7-oxo Lithocholic Acid, NSC 226118) |
| Catalog No.GC39474 |
L'acide 7-cétolithocholique (acide 3α-hydroxy-7-oxo-5β-cholanique), un acide biliaire, peut être absorbé et supprime la production endogène d'acide biliaire et la sécrétion de cholestérol biliaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4651-67-6
Sample solution is provided at 25 µL, 10mM.
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7-Ketolithocholic acid (3α-hydroxy-7-oxygen-5β-cholic acid) is a kind of bile acid, 7-Ketolithocholic acid can be absorbed, 7-ketolithocholic acid inhibits the production of endogenous bile acid, and can affect the secretion of biliary cholesterol[1，2].
After 7-ketolithocholic acid (400 mg/day) was administered orally for 14 days, biliary bile acid composition changed: The proportion of cholic acid decreased (from 45% to 19%), deoxycholic acid decreased (from 15% to 10%), chenodeoxycholic acid increased markedly (from 36% to 59%), ursodeoxycholic acid increased (from 36% to 59%), ursodeoxycholic acid increased (from 2% to 7%), and lithocholic acid increased (from 2% to 5%), while only trace amounts of 7-ketolithocholic acid were detected. During this treatment, the biliary lithogenic index fell from 2.6 to 0.9 and was accompanied by a pronounced drop in biliary cholesterol concentration[2].
References:
[1]. Choucair I, Nemet I, et,al. Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases. J Lipid Res. 2020 Feb;61(2):159-177. doi: 10.1194/jlr.RA119000311. Epub 2019 Dec 9. PMID: 31818878; PMCID: PMC6997600.
[2]. Salen G, Verga D, et,al. Effect of 7-ketolithocholic acid on bile acid metabolism in humans. Gastroenterology. 1982 Aug;83(2):341-7. PMID: 7084613.
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