Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human)) |
| Catalog No.GC32615 |
L'adrénomédulline (AM) (22-52), humaine (22-52-adrénomédulline (humaine)), un analogue tronqué de l'adrénomédulline NH2 terminal, est un antagoniste des récepteurs de l'adrénomédulline et antagonise également le récepteur du peptide lié au gène de la calcitonine (CGRP) dans le membre postérieur vasculaire lit du chat.
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Cas No.: 159899-65-7
Sample solution is provided at 25 µL, 10mM.
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Adrenomedullin (AM) (22-52), human is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.
Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].
[1]. Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42.
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