Apatorsen (Synonyms: OGX-427) |
| Catalog No.GC65035 |
ApatorsenestunoligonucléotideantisensconÇupourselierÀl'ARNm deHsp27,entraÎnantl'inhibitiondelaproductiondelaprotéineHsp27.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1002331-21-6
Sample solution is provided at 25 µL, 10mM.
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Apatorsen is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
[1]. Spigel DR, Shipley DL, Waterhouse DM, et al. A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial. Oncologist. 2019;24(12):e1409-e1416. [2]. Yu EY, Ellard SL, Hotte SJ, et al. A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer. Invest New Drugs. 2018;36(2):278-287.
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