BI-409306 (Synonyms: BI-409306) |
| Catalog No.GC19068 |
BI-409306 (BI-409306) est un inhibiteur puissant et sélectif de la PDE9A, avec une IC50 de 52 nM, et montre une faible activité contre d'autres PDE, telles que PDE1A (IC50, 1,4 μM), PDE1C (IC50, 1,0 μ M), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A et PDE10A (IC50 tous > 10 μM); Le BI-409306 peut être utilisé dans la recherche sur l'amélioration de la mémoire dans les troubles du SNC.
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Cas No.: 1189767-28-9
Sample solution is provided at 25 µL, 10mM.
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BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 uM), PDE1C (IC50, 1.0 uM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 uM); BI-409306 can be used in the research of memory enhancement in CNS disorders.
BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 uM), PDE1C (IC50, 1.0 uM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 uM), and has no obvious effect on 95 non-PDE targets at 10 uM. BI-409306 enhances long-term potentiation (LTP) in rat hippocampal slices[1].
References:
[1]. Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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