BNC105 |
| Catalog No.GC34102 |
Le BNC105 est un inhibiteur de la polymérisation de la tubuline doté de puissantes propriétés antiprolifératives et de perturbation vasculaire tumorale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 945771-74-4
Sample solution is provided at 25 µL, 10mM.
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BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
[1]. Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. [2]. Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. [3]. Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.
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