Bozitinib (Synonyms: PLB-1001; CBT-101; Vebreltinib) |
| Catalog No.GC38894 |
Le bozitinib (PLB-1001) est un inhibiteur hautement sélectif de la c-MET kinase avec une perméabilité de la barrière hémato-encéphalique. Le bozitinib (PLB-1001) est un inhibiteur de petites molécules compétitif pour l'ATP, se lie À la poche de liaison À l'ATP conventionnelle de la superfamille des tyrosine kinases.
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Cas No.: 1440964-89-5
Sample solution is provided at 25 µL, 10mM.
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Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily[1].
Bozitinib (PLB-1001) (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3, has a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways. Western Blot Analysis[1] Cell Line: Human astrocytes (HA) cells
[1]. Hu H, et al. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18.
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