TL4-12 |
| Catalog No.GC50295 |
TL4 12 est un inhibiteur puissant et sélectif de la GCK (germinal center kinase).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1620820-12-3
Sample solution is provided at 25 µL, 10mM.
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Potent MAP4K2 (GCK) inhibitor (IC50 = 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC50 = 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation, in vitro.
Tan et al (2015) Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 58 183 PMID:25075558
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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