C-171 |
| Catalog No.GC46984 |
Le C-171 est un inhibiteur du stimulateur des gènes de l'interféron (STING).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244881-69-2
Sample solution is provided at 25 µL, 10mM.
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C-171 is an inhibitor of stimulator of interferon genes (STING).1,2 It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.1 It selectively reduces human and mouse STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 μM.
1.Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018) 2.Zhang, H., You, Q.-D., and Xu, X.-L.Targeting stimulator of interferon genes (STING): A medicinal chemistry perspectiveJ. Med. Chem.63(8)3785-3816(2019)
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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