JKE-1716 |
Catalog No.GC47478 |
JKE-1716 est un inhibiteur puissant et sélectif de GPX4 contenant de l'acide nitrolique.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2421118-05-8
Sample solution is provided at 25 µL, 10mM.
JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1 JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
Average Rating: 5
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