JKE-1716 |
| Catalog No.GC47478 |
JKE-1716은 강력하고 선택적인 니트로산 함유 GPX4 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2421118-05-8
Sample solution is provided at 25 µL, 10mM.
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JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1 JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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