STING Agonist 1a |
| Catalog No.GC48110 |
STING Agonist 1a (1a) est un stimulateur spécifique des gènes de l'interféron (STING) agoniste.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 652142-94-4
Sample solution is provided at 25 µL, 10mM.
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STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .
1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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