TD-428 |
| Catalog No.GC34319 |
TD-428 est un PROTAC connecté par des ligands pour Cereblon et BRD4. Le TD-428 est un dégradeur BRD4 hautement spécifique avec un DC50 de 0,32 nM. TD-428 est un BET PROTAC, qui comprend TD-106 (un ligand CRBN) lié À JQ1 (un inhibiteur de BET). Le TD-428 induit efficacement la dégradation de la protéine BET.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2334525-50-5
Sample solution is provided at 25 µL, 10mM.
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TD-428 is a highly specific BRD4 degrader with a DC50?of?0.32?nM[1].
TD-428, the BRD4 degrader with TD-106, is highly specific for BET proteins. TD-428 (0.01, 0.1, 1, 10, 100, 1000, and 10000 nM; 72?hours) inhibits the proliferation of 22RV1 cells with a CC50?of??20.1?nM[1].|| Cell Cytotoxicity Assay[1]|| Cell Line:|22RV1 cells|Concentration:|0.01, 0.1, 1, 10, 100, 1000, and 10000 nM|Incubation Time:|72?hours|Result:|Inhibited cell proliferation with a CC50?of?20.1?nM.|| Western Blot Analysis[1]||Cell Line:|U266 cells |Concentration:|1 nM, 10 nM, 100nM, 1000 nM, and 10?μM|Incubation Time:|12?hours|Result:|Induced the degradation of BET proteins.
[1]. Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med Chem. 2019 Mar 15;166:65-74.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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