CBA (Synonyms: CBA, Transient Receptor Potential Melastatin 4 Inhibitor 5, TRPM4 Inhibitor 5) |
| Catalog No.GC50557 |
Le CBA (CBA) est un inhibiteur puissant et sélectif du canal cationique TRPM4, avec une IC50 de 1,5 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 351424-20-9
Sample solution is provided at 25 µL, 10mM.
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Selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.
Bianchi et al (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 11 41 PMID:29996905 |Ozhathil et al (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 175 2504 PMID:29579323
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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