CCT 241533 dihydrochloride |
| Catalog No.GC50085 |
Le dichlorhydrate de CCT 241533 est un inhibiteur compétitif puissant et sélectif de l'ATP de CHK2 avec une IC50 de 3 nM et un Ki de 1,16 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1962925-28-5
Sample solution is provided at 25 µL, 10mM.
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Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.
Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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