Cirtuvivint (Synonyms: SM08502) |
| Catalog No.GC63476 |
Cirtuvivint (SM08502) est un inhibiteur puissant et actif par voie orale de la kinase CDC-like (CLK). Cirtuvivint peut être utilisé pour la recherche sur les tumeurs solides.
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Cas No.: 2143917-62-6
Sample solution is provided at 25 µL, 10mM.
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Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor. Cirtuvivint can be used for solid tumors research[1].
Cirtuvivint (SM08502) inhibits serine and arginine rich splicing factor (SRSF) phosphorylation and disrupted spliceosome activity, which is associated with inhibition of Wnt pathway-related gene and protein expression. Cirtuvivint induces the generation of splicing variants of Wnt pathway genes, suggesting that its mechanism for inhibition of gene expression includes effects on alternative splicing[1].
Orally administered Cirtuvivint (SM08502) significantly inhibits growth of gastrointestinal tumors and decreased SRSF phosphorylation and Wnt pathway gene expression in xenograft mouse models[1].
[1]. Betty Y Tam, et al. The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models. Cancer Lett. 2020 Mar 31;473:186-197.
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