[Des-His1,Glu9]-Glucagon (1-29) amide (trifluoroacetate salt) |
| Catalog No.GC41743 |
[Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes).
Products are for research use only. Not for human use. We do not sell to patients.
![[Des-His1,Glu9]-Glucagon (1-29) amide (trifluoroacetate salt) Chemical Structure](/media/struct/GC4/GC41743.png "[Des-His1,Glu9]-Glucagon (1-29) amide (trifluoroacetate salt) Chemical Structure")
Sample solution is provided at 25 µL, 10mM.
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[Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin .
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