Dihydrocytochalasin B (Synonyms: DCB) |
| Catalog No.GC43461 |
La dihydrocytochalasine B (H2CB) est un inhibiteur de la cytokinèse et modifie la morphologie des cellules, similaire À celle de la cytochalasine B ; n'inhibe pas le transport du glucose. La dihydrocytochalasine B (H2CB) perturbe la structure de l'actine et inhibe la capacité des facteurs de croissance À stimuler la synthèse d'ADN, bloque de manière réversible l'initiation de la synthèse d'ADN. La dihydrocytochalasine B (H2CB) inhibe le transport actif du calcium et provoque une augmentation de Ca2+ dans les raclures muqueuses.
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Cas No.: 39156-67-7
Sample solution is provided at 25 µL, 10mM.
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Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis[2]. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca2+increase in the mucosal scrapings[3].
References:
[1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70.
[2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51.
[3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62.
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