Dihydrocytochalasin B (Synonyms: DCB) |
カタログ番号GC43461
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ジヒドロサイトカラシン B (H2CB) は細胞質分裂阻害剤であり、サイトカラシン B と同様に細胞の形態を変化させます。グルコース輸送を阻害しません。ジヒドロサイトカラシン B (H2CB) は、アクチン構造を破壊し、成長因子が DNA 合成を刺激する能力を阻害し、DNA 合成の開始を可逆的にブロックします。ジヒドロサイトカラシン B (H2CB) は能動的なカルシウム輸送を阻害し、粘膜掻爬で Ca2+ の増加を引き起こす。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 39156-67-7
Sample solution is provided at 25 µL, 10mM.
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Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis[2]. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca2+increase in the mucosal scrapings[3].
References:
[1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70.
[2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51.
[3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62.
| Cas No. | 39156-67-7 | SDF | |
| 同義語 | DCB | ||
| Canonical SMILES | O=C1CC[C@H](O)CCC[C@@H](C)C/C=C/[C@]([C@H](O)C([C@@H](C)[C@@]2([H])[C@H](CC3=CC=CC=C3)NC4=O)=C)([H])[C@@]24O1 | ||
| Formula | C29H39NO5 | M.Wt | 481.6 |
| 溶解度 | DMF: 30 mg/mL,DMF:PBS (pH 7.2) (1:20): 0.05 mg/mL,DMSO: 20 mg/mL,Ethanol: 20 mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.0764 mL | 10.3821 mL | 20.7641 mL |
| 5 mM | 415.3 μL | 2.0764 mL | 4.1528 mL |
| 10 mM | 207.6 μL | 1.0382 mL | 2.0764 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)