DLK-IN-1 |
| Catalog No.GC30913 |
DLK-IN-1 est un inhibiteur sélectif, actif par voie orale, de la double leucine zipper kinase (DLK, MAP3K12), avec un Ki de 3 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1620574-24-4
Sample solution is provided at 25 µL, 10mM.
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DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer's Disease.
[1]. Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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