DRI-C21045 |
| Catalog No.GC39312 |
DRI-C21045 (composé 10) est un inhibiteur puissant et sélectif de l'interaction protéine-protéine costimulation CD40-CD40L (PPI) avec une CI50 de 0,17 μM.
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Cas No.: 2101765-81-3
Sample solution is provided at 25 µL, 10mM.
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DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively[1].
[1]. Chen J, et al. Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction. J Med Chem. 2017 Nov 9;60(21):8906-8922.
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