DRI-C21045 |
| Katalog-Nr.GC39312 |
DRI-C21045 (Verbindung 10) ist ein potenter und selektiver Inhibitor der kostimulatorischen Protein-Protein-Wechselwirkung CD40-CD40L (PPI) mit einem IC50 von 0,17 μM.
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Cas No.: 2101765-81-3
Sample solution is provided at 25 µL, 10mM.
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DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively[1].
[1]. Chen J, et al. Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction. J Med Chem. 2017 Nov 9;60(21):8906-8922.
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