Efaproxiral (RSR13) (Synonyms: RSR 13) |
| Catalog No.GC32887 |
L'éfaproxiral (RSR13) est un modificateur allostérique synthétique de l'hémoglobine (Hb), qui diminue l'affinité de liaison Hb-oxygène (O2) et améliore l'oxygénation des tumeurs hypoxiques pendant la radiothérapie .
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Cas No.: 131179-95-8
Sample solution is provided at 25 µL, 10mM.
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Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.
[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.
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