Efaproxiral (RSR13) (Synonyms: RSR 13) |
| Catalog No.GC32887 |
에파프록시랄(RSR13)은 헤모글로빈(Hb) 합성 알로스테릭 조절제로서 방사선 치료 중 Hb-산소(O2) 결합 친화도를 감소시키고 저산소 종양의 산소화를 향상시킵니다.
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Cas No.: 131179-95-8
Sample solution is provided at 25 µL, 10mM.
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Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.
[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.
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