Elastatinal |
Catalog No.GC18191 |
L'élastatinal est un inhibiteur puissant et compétitif de l'élastase, avec un Ki de 0,21 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 51798-45-9
Sample solution is provided at 25 µL, 10mM.
Elastatinal is a potent inhibitor of pancreatic elastase (Ki = 240 nM) that is produced by various species of Actinomycetes. [1] It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme. [2] [3] Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases.[4] It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.[5]
Reference:
[1]. Umezawa, H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 45, 678-695 (1976).
[2]. Feinstein, G., Malemud, C.J., and Janoff, A. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys. Acta. 429(3), 925-932 (1976).
[3]. Okumura, Y., Ogawa, K., and Uchiya, K. Characterization and primary structure of elastase inhibitor, AFLEI, from Aspergillus flavus. Nishon Ishinkin Gakkai Zasshi 48(1), 13-18 (2007).
[4]. Molla, A., Hellen, C.U.T., and Wimmer, E. Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors. J. Virol. 67(8), 4688-4695 (1993).
[5]. Roy, P., Colas, B., and Durand, P. Purification, kinetical and molecular characterizations of a serine collagenolytic protease from greenshore crag (Carcinus maenas) digestive gland. Comp. Biochem. Physiol. Biochem. Mol. Biol. 115(1), 87-95 (1996).
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