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Eribulin

Catalog No.GC14354

L'éribuline (E7389) est un agent ciblant les microtubules utilisé pour la recherche sur le cancer du sein métastatique. L'éribuline inhibe la prolifération des cellules cancéreuses en liant les protéines des microtubules et les microtubules.

Products are for research use only. Not for human use. We do not sell to patients.

Eribulin Chemical Structure

Cas No.: 253128-41-5

Taille Prix Stock Qté
500μg
185,00 $US
En stock
1mg
234,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Eribulin (E7389) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer. Eribulin (E7389) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

References:
[1]. Okouneva, T., et al., Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther, 2008. 7(7): p. 2003-11.
[2]. Smith, J.A., et al., Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry, 2010. 49(6): p. 1331-7.
[3]. Towle, M.J., et al., Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res, 2011. 71(2): p. 496-505.

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