Fidarestat (SNK 860) |
| Catalog No.GC31487 |
Fidarestat (SNK 860) (SNK 860) est un inhibiteur de l'aldose réductase, avec des IC50 de 26 nM, 33 μM et 1,8 μM pour l'aldose réductase, AKR1B10 et V301L AKR1B10, respectivement; Fidarestat (SNK 860) (SNK 860) a le potentiel de traiter la maladie diabétique.
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Cas No.: 136087-85-9
Sample solution is provided at 25 µL, 10mM.
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Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.
Fidarestat is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively[1].
Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats[2].
[1]. Ruiz FX, et al. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85. [2]. Hotta N, et al. Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Exp Physiol. 1995 Nov;80(6):981-9.
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