RET V804M-IN-1 |
| Catalog No.GC60320 |
RET V804M-IN-1 (composé 5) est un inhibiteur sélectif wt-RET de la kinase RETV804M, avec une IC50 de 20 nM.
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Cas No.: 2414909-94-5
Sample solution is provided at 25 µL, 10mM.
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RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].
RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively[1].
[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.
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