MSA-2 (Synonyms: 5,6-dimethoxy-γ-oxo-benzobthiophene-2-Butanoic Acid) |
| Catalog No.GC61092 |
MSA-2, un agoniste STING non nucléotidique puissant et disponible par voie orale, est lié À STING sous forme de dimère non covalent avec une affinité nanomolaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 129425-81-6
Sample solution is provided at 25 µL, 10mM.
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MSA-2, a potent and orally available non-nucleotide STING agonist, has EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1].
MSA-2 dosed via either PO or SC regimens achieved comparable exposure in both tumor and plasma. MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals[1].MSA-2 (PO: 60 mg/kg or SC: 50 mg/kg; single dose) that effectively inhibits tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor[1]. Animal Model: MC38 tumor-bearing C57BL6 mice[1]
[1]. Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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