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Fluocinolone Acetonide (Synonyms: NSC 92339)

Catalog No.GC11257

L'acétonide de fluocinolone est un dérivé de glucocorticoïde utilisé par voie topique dans le traitement de divers troubles cutanés.

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Fluocinolone Acetonide Chemical Structure

Cas No.: 67-73-2

Taille Prix Stock Qté
10mM (in 1mL DMSO)
34,00 $US
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100mg
49,00 $US
En stock
200mg
80,00 $US
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Fluocinolone Acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders.Target: Glucocorticoid ReceptorFluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin. The Glucocorticoid Receptor(GR) binding affinity (IC50) for Fluocinolone Acetonide(FA) was 2.0 nM, respectively. The values is similar to the GR transactivation EC50 of 0.7 nM for FA, respectively [1, 2].

References:
[1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide
[2]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.

Chemical Properties

Cas No. 67-73-2 SDF
Synonymes NSC 92339
Chemical Name (2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one
Canonical SMILES F[C@@]1([C@@](C([H])([H])[H])(C([H])=C2[H])C3=C([H])C2=O)[C@](C([H])([H])[C@]3([H])F)([H])[C@@]4([H])[C@@](C([H])([H])[C@]1([H])O[H])(C([H])([H])[H])[C@]5(C(C([H])([H])O[H])=O)OC(C([H])([H])[H])(C([H])([H])[H])O[C@]5([H])C4([H])[H]
Formula C24H30F2O6 M.Wt 452.4999
Solubility ≥ 14.55mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.2099 mL 11.0497 mL 22.0995 mL
5 mM 0.442 mL 2.2099 mL 4.4199 mL
10 mM 0.221 mL 1.105 mL 2.2099 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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