Duocarmycin SA |
| Catalog No.GC35912 |
Duocarmycin SA est un puissant antibiotique antitumoral avec une IC50 de 10 pM. La duocarmycine SA est un agent cytotoxique extrêmement puissant capable d'induire une alkylation séquentielle sélective de l'ADN duplex. Duocarmycin SA démontre une cytotoxicité synergique contre les cellules de glioblastome multiforme (GBM) traitées avec un rayonnement protonique in vitro.
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Cas No.: 130288-24-3
Sample solution is provided at 25 µL, 10mM.
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Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].
[1]. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [2]. Boyle KE, et al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692.
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