E3 ligase Ligand 15 (Synonyms: MDM2 ligand 2; E3 ligase Ligand 15) |
| Catalog No.GC35929 |
E3 ligase Ligand 15 (MDM2 ligand 2) est le ligand MDM2 À base de Nutlin 3. Le ligand 15 de la ligase E3 peut être connecté au ligand de la protéine par un lieur pour former des PROTAC.
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Cas No.: 2306390-08-7
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 15 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 15 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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