Interphotoreceptor Retinoid Binding Protein Fragment IRBP |
Catalog No.GC36321 |
Le fragment de protéine de liaison aux rétinoïdes interphotorécepteurs IRBP, un peptide à 20 résidus et un épitope pathogène majeur, est présent dans la première répétition homologue du peptide de la protéine de liaison aux rétinoïdes interphotorécepteurs (IRBP 161–180), qui peut induire une uvéite postérieure (EAU).
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Cas No.: 211426-18-5
Sample solution is provided at 25 µL, 10mM.
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161-180), which can induce posterior uveitis (EAU)[1].
[1]. Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87. [2]. Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85. [3]. Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804.
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