Interphotoreceptor Retinoid Binding Protein Fragment IRBP |
| Katalog-Nr.GC36321 |
Interphotorezeptor-Retinoid-bindendes Proteinfragment IRBP, ein Peptid mit 20 Resten und ein wichtiges pathogenes Epitop, ist in der ersten homologen Wiederholung des Interphotorezeptor-Retinoid-bindenden Proteinpeptids (IRBP 161–180) vorhanden, das eine hintere Uveitis (EAU) induzieren kann.
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Cas No.: 211426-18-5
Sample solution is provided at 25 µL, 10mM.
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Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161-180), which can induce posterior uveitis (EAU)[1].
[1]. Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87. [2]. Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85. [3]. Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804.
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