Neuromedin N (Synonyms: Neuromedin N (rat, mouse, porcine, canine)) |
| Catalog No.GC36726 |
Neuromedin N est un puissant modulateur de la liaison des agonistes des récepteurs de la dopamine D2 dans les membranes néostriées du rat.
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Cas No.: 92169-45-4
Sample solution is provided at 25 µL, 10mM.
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Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Dopamine D2 receptor[1].
Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].
[1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4. [2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44.
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