PLpro inhibitor (Synonyms: PLpro Inhibitor 6) |
| Catalog No.GC36939 |
L'inhibiteur de PLpro est un puissant inhibiteur de la protéase de type papaÏne (PLpro) avec une IC50 de 2,6 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1093070-14-4
Sample solution is provided at 25 µL, 10mM.
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PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.IC50 Value: 2.6 uM [1]Target: PLpro; SARS-CoVin vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].in vivo:
[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24. [2]. http://www.google.com/patents/WO2010022355A1cl=en
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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