Pyridostatin hydrochloride (Synonyms: RR82 hydrochloride) |
Catalog No.GC37043 |
Le chlorhydrate de pyridostatine (RR82) est un agent stabilisant de l'ADN G-quadruplex (Kd = 490 nM). Le chlorhydrate de pyridostatine favorise l'arrêt de la croissance des cellules cancéreuses humaines en induisant des dommages À l'ADN dépendant de la réplication et de la transcription. Le chlorhydrate de pyridostatine cible le proto-oncogène Src. Le chlorhydrate de pyridostatine a réduit les niveaux de protéine SRC et la motilité cellulaire dépendante du SRC dans les cellules cancéreuses du sein humain.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1781882-65-2
Sample solution is provided at 25 µL, 10mM.
Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. Kd: 490 nM (G-quadruplexe)[1]
Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3].
[1]. Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011 Aug 28;3(10):782-7. [2]. Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017 Sep 12;9(9):1957-1970. [3]. Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012 Feb 5;8(3):301-10.
Average Rating: 5
(Based on Reviews and 2 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *