O-7460 |
| Catalog No.GC44481 |
O-7460 est un inhibiteur puissant et sélectif de DAGLα, avec une IC50 de 0,69 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1572051-31-0
Sample solution is provided at 25 µL, 10mM.
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In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 µM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 µM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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